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In simple terms, herpes simplex 1 is most commonly known as a "cold sore", while herpes simplex 2 is the one known by the public as "herpes", or "genital herpes".
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The structure of herpes viruses consists of a relatively large double-stranded, linear DNA genome encased within an icosahedral protein cage called the capsid, which is wrapped in a lipid bilayer called the envelope.
The envelope is joined to the capsid by means of a tegument. These genes encode a variety of proteins involved in forming the capsid, tegument and envelope of the virus, as well as controlling the replication and infectivity of the virus.
HSV-1 and -2 are transmitted by contact with an infected person who has reactivations of the virus.
Herpes simplex virus (HSV)-2 is periodically shed in the human genital tract, most often asymptomatically.
The envelope covering the virus particle then fuses with the cell membrane, creating a pore through which the contents of the viral envelope enters the host cell.
The sequential stages of HSV entry are analogous to those of other viruses.
88% of patients treated with valaciclovir had no recognized signs or symptoms versus 77% for placebo.
Studies on discordant partners (one infected with HSV-2, one not) show that the transmission rate is approximately 5 per 10,000 sexual contacts. 2001;285(24):3197) Atypical symptoms are often attributed to other causes such as a yeast infection.
After the initial or primary infection, some infected people experience sporadic episodes of viral reactivation or outbreaks.Tags: Adult Dating, affair dating, sex dating